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The PhD course in Traslational Specialistic Medicine “G.B. Morgagni”

The PhD course in Traslational Specialistic Medicine “G.B. Morgagni” offers highly competitive PhD. Programs in the biomedical field of Cardiovascular Sciences, Clinical and Traslational Neurosciences, Endocrine and Metabolic Sciences, Biostatistics and Clinical Epidemiology, Thoracic and Pulmonary Sciences.

The main objective of the course is to form top-level scientists in the biomedical disciplines and offers a wide range of facilities to perform research in clinical and experimental medicine from basic science to clinics with particular emphasis on translational medicine. At the end of their research program the Ph.D. Students acquire specific knowledge concerning basic sciences and molecular medicine, technical laboratory skills, and a research method in Medicine and Surgery to be applied in the prevention, diagnosis and therapy of human diseases. Using a multidisciplinary approach to biomedical sciences, competences in epidemiology, genetics, biology and molecular pathology, regenerative medicine, physiopathology, diagnostics and therapy are integrated.

The Ph. Doctors will gain skills for designing experimental protocols, for directing research projects and for treating patients with the power of the experimental scientific method. The research project is carried out under the supervision of one of the Faculty members. The PhD course recognize a three-step training approach for the PhD students during the three-year course:

  • an initial phase of training and general culture, including elements and methodologies of interest common to the different curricula, as well as acquisition of methodologies with the potential of building one's curriculum, oriented in such a way to acquired knowledge, particularly in the basic sciences such as genetics, molecular biology, biotechnology and regenerative medicine;
  • a second phase for acquisition of technology and methodology in basic and clinical sciences, specific to the institutional objectives and to those of research, integrated with the participation of specialized courses including seminars, conferences, and meetings in the following areas: cardiovascular sciences; endocrinological and diabetological sciences; neurosciences; biostatistics and clinical epidemiology; thoracic and pulmonary sciences;
  • a third phase acquisition of a complete research methodology through the allocation of Ph.D. students in different ongoing research groups within the departments of the Ph.D. Course. Such activities will culminate in the drawing up of the doctoral thesis. The research activities foresees a period of research in external national and international institutions.

 

The teaching activity includes frontal lessons, lectures, seminars, clinico‐pathological conferences, a summer school during the first year, an autumn school at the second year, and a winter school at the third year. The remaining time must be devoted to the research activity (Basic laboratories, Clinical and Diagnostic Activities).

 


 

The Ph.D. Course in Traslational Specialistic Medicine “G.B. Morgagni” is organized in 5 curricula:

  • Curriculum: Cardiovascular Sciences,
  • Curriculum: Clinical and Traslational Neurosciences,
  • Curriculum: Endocrine and Metabolic Sciences,
  • Curriculum: Biostatistics and Clinic Epidemiology,
  • Curriculum: Thoracic and Pulmonary Sciences.

 

Specific research fields are as follow:

 

CARDIOVASCULAR SCIENCES

Experimental and applied molecular Cardiology and cell biology of the heart. Cardiomyopathies. Genetics of heredo-familial cardiomyopathies and myocarditis. Sudden death in the young and in the athletes. Regenerative medicine. Heart transplantation. Cardiovascular physiopathology. Interventional cardiology, arrhythmology, Congenital heart diseases. In vivo Cardiovascular imaging, Cardiovascular pathology. Neuropathology. The use of anatomic-pathological research techniques in the study of cardiovascular diseases: Autoptic findings, histological techniques, immune-histochemical procedures, confocal optical microscopy, morphometry, serial histological study of conduction tissue, transmission and scanning electron microscopy. Diagnostic methods using biological and molecular genetics applied to pathological anatomy. Cardiovascular surgery, Mechanical assistance, artificial heart. Valve prosthesis and tissue engineering. Angiology: Biology and physiopathology of the arterial wall, expression of molecular markers in atherosclerosis and in restenosis. Vascular Surgery: Experimental vascular pathology. Medical anthropology, clinical anthropometry. Paleopathology and anthropological museology.
Coordinator of the Curriculum: Prof. Annalisa Angelini (email: annalisa.angelini@unipd.it)

 

CLINICAL and TRASLATIONAL NEUROSCIENCES

Clinical Neurobiology and Neurogenetics: the genetic localization of different neurological diseases and the study of candidate genes. The study of pathogenetic mutations: genotype-phenotype correlations. Genetic expression studies using microarrays and real-time PCR analysis. Neuromuscular diseases: etio-pathogenetic mechanisms in the various forms of muscular dystrophy, of motor neuron diseases, mitochondrial and metabolic diseases, and peripheral neuropathies. Neuroimmunology: markers of immunologic damage in myasthenia gravis and peripheral neuropathies. Neurotoxic complications of chemotherapy in patients with cancer. Neurophysiopathology: characterization of the types of muscular fibers and of the factors of atrophy and hypertrophy. Intervention in the reparative processes of the central and peripheral nervous system of stem cells. Receptors of the central and peripheral nervous system. Otorhinolaryngology: Ototoxicity and otoprotection on sensory hair cells and neurons involved in auditory signal transduction. Mechanisms of cisplatin-induced ototoxicity and otoprotection. Regenerative medicine using nanoparticles to improve drug delivery to the organo of Corti and study of the potential toxic effects of these nanoparticles at high concentrations in vitro and in vivo, and their effects on cell metabolism. Cochlear implantation: development of surgical approaches and neurophysiological testing. Biological factors influencing tumor proliferation in cranial nerves to derive predictors of tumor growth in term of prognosis and to achieve high functional (facial nerve and hearing) preservation rates.The study of vestibulogy associated malfunctions and disorders.
Coordinator of the Curriculum: Prof. Elena Pegoraro (email: elena.pegoraro@unipd.it)

 

ENDOCRINE and METABOLIC SCIENCES

Clinical research in the endocrinological field: insulin resistance, gut hormones, the gut-vascular barrier; effects of hormones on intermediate metabolism; the links between aging/senescence and hormonal control of metabolism; The pathogenesis of the chronic complications of diabetes: the role of hyperglycemia, of the diacil glycerol pathway and protein kinase C, of oxidative stress; Physiopathology of endothelial dysfunction in diabetes, endothelial dysfunction in conduction arteries, in coronary microcirculation, circulating progenitor cells in relation to diabetic micro and macro-angiopathy; Diabetic cardiomyopathy: the effects of postprandial metabolism on coronary circulation physiopathology; The epidemiology and genetics of diabetes and of its chronic complications: the study of polymorphysms and cell alterations making the patient sensitive to renal damage; The effects of kidney-pancreas transplant and isolated pancreas cells on intermediate metabolism and on diabetic complications; Proteomic techniques in the analysis of gene expression: separation of median proteins. Biodimensional electrophoresis for the study of cell protein patterns and of the diverse protein isoforms in cultured fibroblasts obtained from normal and diabetic subjects. The study of in vivo and in vitro glycooxidation mechanisms using mass spectrometry; Circulating cells in diabetic complications: the study of endothelial progenitors, monocyte polarization, neutrophil phenotype and kinetics, the bone marrow status in diabetes.
Coordinator of the Curriculum: Prof. Angelo Avogaro (email: angelo.avogaro@unipd.it)

 

BIOSTATISTICS and CLINICAL EPIDEMIOLOGY

Biostatistics and clinical epidemiology with the application of sound statistical and mathematical methods to the analysis of complex bio-medical phenomena. Development of new methods for giving solutions to novel problems, including data mining and predictive modelling. The objective will be to advance statistical science and its application to problems of human health and disease for improving public’s health.
Coordinator of the Curriculum: Prof. Dario Gregori (email: dario.gregori@unipd.it)

 

THORACIC and PULMONARY SCIENCES

Pathogenesis of obstructive lung diseases (asthma, chronic obstructive lung disease -COPD and cystic fibrosis) and interstitial lung diseases (pneumoconiosis, sarcoidosis and idiopathic pulmonary fibrosis). Study of the immunological (innate and adaptive) mechanisms involved in these diseases by structural and molecular analysis of lung biopsies (bronchial, transbronchial and surgical), bronchoalveolar lavage (BAL) and explanted lungs using advanced technologies such as digestion and laser or manual dissection of lung tissue, immunohistochemistry, cytofluorimetry, next-generation sequencing and multiplex real-time polymerase chain reaction. Relationship between structural or molecular features and clinical or functional characteristics for a better prognostic stratification of patients. Morphological, molecular and genetic analysis in different type of neoplastic disorders (lung cancer, thymoma and mesothelioma) in order to predict prognosis and response to checkpoint inhibitors. Establishment of tumor xenografts in immunodeficient murine experimental model. Ex-vivo lung perfusion (EVLP) in lung transplantation and study of the physiological process that occur in the organ during normothermic perfusion to improve the pulmonary graft quality. Surgical reconstruction techniques of chest wall, trachea and bronchi resected for inflammatory, infectious or neoplastic processes. Multidisciplinary cooperation (pulmonologists, thoracic surgeons, pathologists and radiologists) for a more accurate interpretation of data.
Coordinator of the Curriculum: Prof. Marina Saetta (email: marina.saetta@unipd.it)

 


Attività Formativa (novembre-dicembre 2015)

Attività Formativa (febbraio-giugno 2016)

Summer School 2016

Attività Formativa (2016-2017)

Attività Formativa (2017-2018)



For contact details:

 

Prof. Annalisa Angelini (Director)
Associate Professor, Cardiovascular Pathology
Department of Cardiac, Thoracic and Vascular Sciences
University of Padua Medical School
Via A. Gabelli, 61 35121 Padova, Italy
Phone +39 049 8272260
Fax +39 049 8272205
E-mail: annalisa.angelini@unipd.it

 

Prof. Martina Perazzolo Marra (ViceDirector)
Associate Professor, Cardiology
Department of Cardiac, Thoracic and Vascular Sciences
University of Padua Medical School
Via N. Giustiniani, 2 35121 Padova, Italy
Phone +39 049 8218642
Fax +39 049 8211802
E-mail: martina.perazzolomarra@unipd.it

 

Documentation - PhD course in Traslational Specialistic Medicine "G.B. Morgagni" Download HOME E TRAINING AIMS.pdf Download CURRICULUM.pdf Download TEACHING STAFF.pdf Download TEACHING ACTIVITIES.pdf

Documentation - PhD course in Medical Clinical and Experimental Sciences (XXIX cycle) Download GUIDE LINES.pdf Download HOME and TRAINING AIMS.pdf Download COURSES.pdf Download TEACHING ACTIVITY.pdf Download TEACHING STAFF.pdf